Correlation of Apo E Gene Polymorphism with Recurrent Acute Coronary Syndrome

Background: Recurrent cardiovascular disease (CVD) incidence puts patients at higher risk for mortality and morbidity. One of the CVD symptoms is acute coronary syndrome (ACS). Many genetic polymorphisms are factors. This study’s purpose was to investigate correlation between recurrent ACS apolipoprotein E (ApoE) gene polymorphism. Method: Case-control design used in this study. About 90 who visited cardiology internal medicine clinics UNAIR Hospital Surabaya, Indonesia, served as study's subjects. There were 30 with ACS, a single no history disease. Afterward, using polymerase chain reaction-restriction fragment length method, ApoE polymorphism examination carried out. The Tropical Disease Center Laboratory conducted all laboratory testing. Results: In group, genotype patterns 5 subjects ε2ε2 (16.67%), 23 ε3ε3 (76.66%), 2 ε4ε4 (6.67%). Meanwhile, 6 (20%), 22 (73.4%), 1 subject (3.33%), ε2ε3 (3.33%). And, non- were4 (13.34%), 25 (83.33%), and1 by Chi-square analysis (p > 0.05). Conclusion: cannot significantly affect incidence.